Chen Li-Li

Institute of Marine Biology

	Assistant Prof. Chen Li-Li
	Tel: +886-2-24622192 ext.5302
	E-Mail: joechen@ntou.edu.tw
	Contact Address:	Institute of Marine Biology, National Taiwan Ocean University, No. 2, Pei-Ning Road, Keelung 202-24, Taiwan (R.O.C.)

· PhD, Institute of Zoology, National Taiwan University. Dissertation: “Expression and Characterization of vp35 and np1 genes of White Spot Syndrome Virus (WSSV)”, 2001.

· August 2007 – Present: Assistant Professor, Institute of Marine Biology, National Taiwan Ocean University

· January 2007 – December 2010: Co-director, Sub-project “Subsidy Project of Quality Programs of General Education”, General Education Program Office, Advisory Office, Ministry of Education

· August 2004 – July 2007: Assistant Professor, Department of Biomedical Sciences, Chung Shan Medical University

· February 2003 – July 2004: Instructor, Department of Life Science, National Taiwan University

· August 2001 – July 2004: Postdoctoral researcher, Institute of Zoology, National Taiwan University

My collaborative work with Prof. Chu-Fang Lo in National Taiwan University has focused on the study of white spot syndrome virus (WSSV), which is the causative agent of one of the world's most serious shrimp diseases. The scope of our research includes not only the virus itself, but extends to viral transmission and control.

1. Sirirustananun, N., Chen, J. C.* Lin Y. C., Yeh S. T., Liou, C. H., Chen, L. L., Sim, S. S., Chiew, S. L. (2011). Dietary administration of a Gracilaria tenuistipitata extract enhances the immune response and resistance against Vibrio alginolyticus and white spot syndrome virus in the white shrimp Litopenaeus vannamei. Fish Shellfish Immunol. (In press) (SCI)

2. Lin Y. C., Yeh S. T., Li C. C., Chen, L. L., Cheng A. C., Chen, J. C.* (2011). An immersin of Gracilaria tenuistipitata extract improves the immunity and survival of white shrimp Litopenaeus vannamei challenged with white spot syndrome virus. Fish Shellfish Immunol. (In press) (SCI)

3. Huynh, T. G., Yeh, S. T., Lin, Y. C., Shyu, J. F., Chen, L. L., Chen, J. C.* (2011). White shrimp Litopenaeus vannamei immersed in seawater containing Sargassum hemiphylum var. chinese powder and its extract showed increased immunity and resistance against Vibrio alginolyticus and white spot syndrome virus. Fish Shellfish Immunol. 31, 286-293. (SCI)

4. Huang, W. J., Leu, J. H., Tsau, M. T., Chen, J. C., and Chen, L. L.* (2011). Differential expression of LvHSP60 in shrimp in response to environmental stress. Fish Shellfish Immunol. 30, 576-582. (SCI)

6. Chen, K. Y., Hsu, T. C., Huang, P. Y., Kang, S. T., Lo, C. F., Huang, W. P. and Chen, L. L.* (2009). Penaeus monodon chitin-binding protein (PmCBP) is involved in white spot syndrome virus (WSSV) infection. Fish Shellfish Immunol. 27, 460-465. (SCI) (國科會補助之研究計畫，NSC 96-2311-B-019-003)

7. Kang, S. T., Leu, J. H., Wang, H. C., Chen, L. L., Kou, G. H.*, and Lo, C. F* (2009). Polycistronic mRNAs and internal ribosome entry site elements (IRES) are widely used by white spot syndrome virus (WSSV) structural protein genes. Virology 387, 353-363. (SCI)

8. Huang, P. Y., Kang, S. T., Chen, W. Y., Hsu, T. C., Lo, C. F., Liu, K. F., and Chen, L. L.* (2008). Identification of the small heat shock protein, HSP21, of shrimp Penaeus monodon and the gene expression of HSP21 is inactivated after white spot syndrome virus (WSSV) infection. Fish Shellfish Immunol. 25, 250-257. (SCI)

9. Chen, L. L.*, Lu, L. C., Wu, W. J., Lo, C. F., and Huang, W. P. (2007). White spot syndrome virus envelope protein VP53A interacts with Penaeus monodon chitin-binding protein (PmCBP). Dis. Aquat. Org. 74, 171-178. (SCI) (國科會補助之研究計畫，NSC 93-2311-B-040-011與NSC 94-2311-B-040-011)

10. Chen, L. L., Hsia, H. L., Hsu, H. C., Chang C. F., Peng, S. E., Kou, G. H., and Lo, C. F*. (2004). Susceptibility of Marsupenaeus japonicus, P. monodon, and P. semisulcatus to white spot syndrome virus (WSSV). J. Fish. Soc. Taiwan 31, 101-114.

11. Hsia, H. L.*, Chen, L. L.*, Peng, S. E., Lo, C. F. and Kou, G. H. (2003) Comparison of infectious hypodermal and hematopoietic necrosis virus (IHHNV) Taiwan isolates with other isolates. Fish Pathol. 38, 177-179. (*Equal contribution) (SCI)

12. Chen, L. L., Wang, H. C., Huang, C. J., Peng, S. E., Chen, Y. G., Lin, S. J., Chen, W. Y., Dai, C. F., Yu, H. T., Wang, C. H., Lo, C. F. and Kou, G. H. (2002). Transcriptional analysis of the DNA polymerase gene of shrimp white spot syndrome virus (WSSV). Virology 301, 136-147. (SCI)

13. Chen, L. L., Leu, J. H., Huang, C. J., Chou, C. M., Chen, S. M., Wang, C. H., Lo, C. F., and Kou, G. H. (2002). Identification of a nucleocapsid protein (VP35) gene of shrimp white spot syndrome virus and characterization of the motif important for targeting vp35 to the nuclei of transfected insect cells. Virology 293, 44-53. (SCI)

14. Peng, S. E., Lo, C. F., Lin, S. C., Chen, L. L., Chang, Y. S., Liu, K. F., Su, M. S., Kou, G. H. (2001). Performance of WSSV-infected and WSSV-negative Penaeus monodon postlarvae in culture pond. Dis. Aquat. Org. 46, 165-172. (SCI)

15. Chen, L. L., Lo, C. F., Chiu, Y. L., Chang, C. F., Kou, G. H. (2000). Natural and experimental infection of white spot syndrome virus (WSSV) in benthic larvae of mud crab Scylla serrata. Dis. Aquat. Org. 40, 157-161. (SCI)

16. Hsu, H. C., Lo, C. F., Lin, S. C., Liu, K. F., Peng, S. E., Chang, Y. S., Chen, L. L., Liu, W. J., and Kou, G. H. (1999). Studies on effective PCR screening strategies for white spot syndrome virus (WSSV) detection in Penaeus monodon brooders. Dis. Aquat. Org. 39, 13-19. (SCI)

1. Huang P. Y., and Chen, L. L.* (2011). The role of L. vannamei chitin-binding protein (LvCBP) in white spot syndrome virus (WSSV) infection. 9th Asian Fisheries & Aquaculture Forum, Shanghai, China. Apr 21-25.

2. Huang, H. T., Huang P. Y., and Chen, L. L.* (2011). The glucose transporter 1 is a receptor for WSSV. 9th Asian Fisheries & Aquaculture Forum, Shanghai, China. Apr 21-25.

3. Kou, T. Y., and Chen, L. L.* (2011). Identification of shrimp glucose transproter 1 in sf-9 cell. 9th Asian Fisheries & Aquaculture Forum, Shanghai, China. Apr 21-25.

4. 黃懷葶，黃博鈺，詹舒涵，康詩婷，陳歷歷*。(2010)。醣通道蛋白1與蝦白點症病毒封套蛋白VP53A結合關係之探討。台灣水產學會學術論文發表會，基隆，台灣，中華民國。12月11日。

5. 黃博鈺，陳歷歷*。(2010)。白蝦幾丁質結合蛋白(LvCBP)與蝦白點症病毒(WSSV)之封套蛋白結合之探討。台灣水產學會學術論文發表會，基隆，台灣，中華民國。12月11日。

6. 曹明通，黃偉邦*，陳歷歷*。(2010)。蝦自噬作用基因ATG8之選殖與分析。台灣水產學會學術論文發表會，基隆，台灣，中華民國。12月11日。

7. 陳歷歷*，陳冠佑，黃博鈺，黃懷葶。(2010)。葡萄醣運輸蛋白參與白點症病毒入侵寄主細胞機轉之研究。第四屆海峽兩岸魚類生理與養殖研討會，長沙，湖南，中國。10月24-30日。Invited Speaker

8. 黃琬茹、陳歷歷*。(2009)。熱休克蛋白60於白點症病毒感染蝦中之研究。台灣水產學會學術論文發表會，高雄，台灣，中華民國。12月19-20日。

9. Chen, L. L.*, Chen. K. Y., and Huang, P. Y. (2009). Penaeus monodon chitin-binding protein (PmCBP) is involved in white spot syndrome virus (WSSV) infection. Third Annual Meeting of the Thailand-Taiwan Shrimp Research Group. Taipei, Taiwan. Dec 15. Invited Speaker

10. Chen. K. Y., and Chen, L. L.* (2009). The functional analysis of Litopenaeus vannamei chitin-binding protein (LvCBP) in white spot syndrome virus (WSSV)-infected shrimp. Asian-Pacific Aquaculture 2009, Kuala Lumpur, Malaysia. Nov 3-6.

11. Huang, P. Y. and Chen, L. L.* (2009). Analysis of protein interaction between Penaeus monodon chitin binding protein (PmCBP) and proteins of white spot syndrome virus (WSSV). Asian-Pacific Aquaculture 2009, Kuala Lumpur, Malaysia. Nov 3-6.

12. 陳歷歷*，陳冠佑，黃博鈺。(2009)。白點症病毒入侵寄主細胞機制之探討。第三屆海峽兩岸魚類生理與養殖研討會，基隆，台灣，中華民國。10月19-21日。Invited Speaker

13. Chen, L. L.*, Hsu, T. C., Chen, K. Y., and Huang, P. Y. (2009). PmCBP involves in WSSV infection. Taiwan & Italy Conference on Marine Biology. Keelung, Taiwan. May 25-26. Invited Speaker

14. 陳冠佑，許台慶，陳歷歷。(2008)。抗白點症病毒胜肽疫苗之測試分析。台灣水產學會學術論文發表會，台北，台灣，中華民國。12月20日。

15. Chen, L. L.*, Chen, K. Y., and Hsu, T. C. (2008). Does PmCBP mediate WSSV infection? 2008 Women in Marine Science and Biotechnology Academic Conference and Career Development. Keelung, Taiwan. Oct 27-28. Invited Speaker

17. Huang, P. Y., Kang, S. T., Chen, W. Y., Hsu, T. C., Lo, C. F., and Chen, L. L.* (2008). Identification of the small heat shock protein, HSP21, of shrimp Penaeus monodon and the gene expression of HSP21 is inactivated after white spot syndrome virus (WSSV) infection. Seventh Symposium on Diseases in Asian Aquaculture (DAA VII), Taipei, Taiwan. Jun 22-26.

18. Chen, L. L.* (2008). Identification the small heat shock protein of shrimp Penaeus monodon. World Aquaculture 2008, Busan, Korea. May 19-23.

19. Lo, C. F., Chen, L. L., Chang, Y. S., Wang, H. C. and Kou, G. H. (2003). White spot syndrome virus: viral gene expression and host response. 6^th International Marine Biotechnology Conference, Chiba and Tokyo, Japan, Sep 21-27.

20. Lin, A. T., Yii, D. M., Chen, L. L., Chang, Y. S., Lo, C. F., Kou, G. H. (2003). DNA microarrays of the white spot syndrome virus genome: characterization of the temporal class of gene expression. Proceedings of Marine Biotechnology Conference 2003, Japanese Society for Marine Biotechnology and Japan Industrial Technology Association (JITA) pp 132.

21. Chen, L. L. (2002). Transcriptional analysis of the DNA polymerase gene of shrimp white spot syndrome virus (WSSV). 5^th Symposium on Diseases in Asian Aquaculture, Gold Coast, Australia. Nov 24-28.

22. Chen, L. L., Leu, J. H., Huang, C. J., Chou, C. M., Wang, C. H., Lo, C. F., and Kou, G. H. (2001). Identification of a nucleocapsid protein (VP35) gene of shrimp white spot syndrome virus and characterization of the motif important for targeting vp35 to the nuclei of transfected insect cells. International Marine Biotechnology Symposium, Taipei, Taiwan, ROC.

23. 陳歷歷，羅竹芳，郭光雄。(1998)。台灣南部沿海鋸緣青蟳 (Scylla serrata) 感染白點症病毒 (WSSV) 之研究。台灣省水產學會學術論文發表會，台北，台灣，中華民國。

24. Kou, G. H., Chen, L. L., and Lo, C. F. (1997). Early vegetative stages of Pleistophora anguillarum (Microspora): Characterization and major antigens recognized by antisera from Japanese eel (Anguilla japonica) with “beko” disease. World Aquaculture Society, Seattle, USA.