發表之專業學術性著作

 期刊論文：

1.Wang, C. H., Lo, C. F., Leu, J. H., Chou, C. M., Yeh, P. Y., Chou, H. Y., Tung, M. C., Chang, C. F., Su, M. S., and Kou, G. H. Purification and genomic analysis of baculovirus associated with white spot syndrome (WSBV) Penaeus monodon. Disease of Aquatic Organisms 1995; 23: 239-242.

2.Leu, L. H. Lee, M. S., Chen, K. T., Chang, G. D., Chou, C. K., and Huang. C. J. Genomic structure of carp mitogen-activated protein kinase I gene. Biochimica et Biophysica Acta 1996; 1203: 133-136.

3.Lo, C. F., Leu, J. H., Ho, C. H., Chen, C. H., Peng, S. E., Chen, Y. T., Chou, C. M., Yeh, P. Y., Huang, C. J., Chou, H. Y., Wang, C. H., and Kou, G. H. Detection of baculovirus associated with white spot syndrome (WSBV) in penaeid shrimps using polyemrase chain reaction. Disease of Aquatic Organisms 1996 25:133-141.

4.Chang, M. S., Chang, G. D., Leu, J. H., Huang, F. L., Chou, C. K., Huang, C. J., and Lo, T. B. Expression, characterization, and genomic structure of carp JAK1 kinase gene. DNA and Cell Biology 1996;15: 827-844.

5.Leu, J. H., Chang, M. S., Chang, G. D., Chou, C. K., and Huang, C. J.  Genomic structure and sequence of the JAK1 kinase of the round-spotted Pufferfish (Tetraodon fluviatilis) Biochimica et Biophysica Acta 1997; 1395: 50-56

6.Chang, M. S., Leu, J. H., Yao, C. W., Huang, F. L., and Huang, C. J.  Genomic structure of c-fos gene of the round-spotted pufferfish,Tetraodon nigroviridis (Syn. T. fluviatilis) Zoological Studies 1997; 36: 159-169

7.Yao, J. W., Leu, J. H., Chin, C., Chou, C. K., and Huang, C. J. Round-spotted pufferfish ( Tetraodon fluviatilis ) snf5 gene is oriented in a tail-to-tail manner with the set gene which encodes an inhibitor of protein phosphatase 2A. DNA and Cell Biology 1997;17: 69-82

8.Chou, C. M., Lin, W. C., Leu, J. H., Su, T. L., Chou, C. K., and Huang, C. J. Isolation and identification of novel protein kinase genes from the round-spotted pufferfish (Tetraodon fluviatilis) genomic DNA. Journal of Biomedical Science 1998; 5: 127-134.

9.Yeh M. S., Huang C.J., Leu J. H., Lee Y. C., and Tsai I. H. Molecular cloning and characterization of a hemolymph clottable protein from tiger shrimp (Penaeus monodon). European Journal of Biochemistry. 1999; 266(2):624-633.

10.Leu, J. H ., Yan, S. J., Lee, T. F., Chou, C. M., Chen, S. T., Hwang, P. P., Chou, C. K., and Huang. C. J. Complete genomic organization and promoter analysis of the round-spotted pufferfish JAK1, JAK2, JAK3, and TYK2 Genes. DNA and Cell Biology 2000;19: 431-446.

11.Tsai, S. C., Leu J. H., Chou, C. M., Yeh, M. S., Huang, F. L., Huang, C. J. Genomic organization and the promoter region of the round-spotted pufferfish (Tetraodon fluviatilis) CDC37 gene. Biochimica et Biophysica Acta 2000;1494(1-2):144-8.

12.Tsai M.F., Yu H.T., Tzeng H. F., Leu J. H., Chou C. M, Huang C. J., Wang C. H., Lin J. Y., Kou G. H., Lo C. F. Identification and characterization of a shrimp white spot syndrome virus (WSSV) gene that encodes a novel chimeric polypeptide of cellular-type thymidine kinase and thymidylate kinase. Virology. 2000; 277(1):100-10.

13.Chen L. L., Leu J. H., Huang C. J., Chou C. M., Chen S. M., Wang C. H., Lo C. F., Kou G. H. Identification of a nucleocapsid protein (VP35) gene of shrimp white spot syndrome virus and characterization of the motif important for targeting VP35 to the nuclei of transfected insect cells. Virology. 2002; 293(1):44-53

14.Feng SH, Leu JH, Yang CH, Fang MJ, Huang CJ, Hwang PP. Gene expression of Na+-K+-ATPase alpha 1 and alpha 3 subunits in gills of the teleost Oreochromis mossambicus, adapted to different environmental salinities. Mar Biotechnol (NY). 2002;4(4):379-91.

15.Sung S.C., Fan T.J., Chou C. M., Leu J.H., Hsu Y.L., Chen S.T., Hsieh Y.C., Huang C.J. Genomic structure, expression and characterization of a STAT5 homologue from pufferfish (Tetraodon fluviatilis). European Journal of Biochemistry 2003; 270(2):239-52

16.Tsai J.M., Wang H.C., Leu J.H., Wang Andrew H.J., Kou G.H., and Lo C.F. Genomic and proteomic analysis of structural proteins of shrimp white spot syndrome virus. Journal of Virology 2004;78(20):11360-70.

17.Leu J.H., Tsai J.M., Wang H.C., Wang Andrew H.J., Wang C.H., Kou G.H., and Lo C.F. The unique stacked rings in the nucleocapsid of the WSSV virion are formed by the major structural protein VP664, the largest viral structural protein ever found. Journal of Virology 2005;79(1):140-9.

18.Tsai J.M., Wang H.C., Leu J.H., Wang A.H., Zhuang Y., Walker P.J., Kou G.H., Lo C.F. Identification of the nucleocapsid, tegument, and envelope proteins of the shrimp white spot syndrome virus virion. Journal of Virology 2006;80(6):3021-9.

19.Wang H.C., Wang H.C., Leu J.H., Kou G.H., Wang A.H., Lo C.F. Protein expression profiling of the shrimp cellular response to white spot syndrome virus infection. Developmental and Comparative Immunology 2007;31(7):672-86.

20.Leu J.H., Chang C.C., Wu J.L., Hsu C.W., Hirono I., Aoki T., Juan H.F., Lo C.F., Kou G.H., Huang H.C. Comparative analysis of differentially expressed genes in normal and white spot syndrome virus infected Penaeus monodon. BMC Genomics 2007;8(1):120

21.Leu J.H., Kuo Y.C., Kou G.H., Lo C.F. Molecular cloning and characterization of an inhibitor of apoptosis protein (IAP) from the tiger shrimp, Penaeus monodon. Developmental and Comparative Immunology 2008; 32(2): 121-133

22.Leu J.H., Wang H.C., Kou G.H., Lo C.F. Penaeus monodon caspase is targeted by a white spot syndrome virus anti-apoptosis protein. Developmental and Comparative Immunology 2008; 32(5): 476-486

23.Chen W.Y., Ho K.C., Leu J.H., Liu K.F., Wang H.C., Kou G.H., Lo C.F. WSSV infection activates STAT in shrimp. Developmental and Comparative Immunology 2008;32(10):1142-50.

24.Liu W.J., Chang Y.S., Wang H.C., Leu J.H., Kou G.H., Lo C.F. Transactivation, dimerization, and DNA-binding activity of white spot syndrome virus immediate-early protein IE1. Journal of Virology 2008;82(22):11362-73.

25.Wang H.C., Wang H.C., Ko T.P., Lee Y.M., Leu J.H., Ho C.H., Huang W.P., Lo C.F., Wang A.H. White spot syndrome virus protein ICP11: A histone-binding DNA mimic that disrupts nucleosome assembly. Proc Natl Acad Sci USA. 2008;105(52):20758-63. 

26.Kang S.T., Leu J.H., Wang H.C., Chen L.L., Kou G.H., Lo C.F. Polycistronic mRNAs and internal ribosome entry site elements (IRES) are widely used by white spot syndrome virus (WSSV) structural protein genes. Virology. 2009; 387(2):353-63.

27.Leu J.H., Chen L.L., Lin Y.R., Kou G.H., Lo C.F. Molecular mechanism of the interactions between white spot syndrome virus anti-apoptosis protein AAP-1 (WSSV449) and shrimp effector caspase. Developmental and Comparative Immunology 2010 May 28. [Epub ahead of print]

 研討會論文：

1.Leu J.H., Tsai J.M., Wang H.C., Wang Andrew H.J., Wang C.H., Kou G.H., and Lo C.F. “VP664, the largest viral structural protein ever found, is the major nucleocapsid protein of WSSV” in 7th Asian Fisheries Forum 04. (30 November-4 December 2004). Penang, Malysia. Oral presentation.

2.Leu J.H., Kou G.H., Lo C.F.. “Molecular cloning and characterization of an inhibitor of apoptosis (IAP) gene from the tiger shrimp, Penaeus monodon” in 6th Symposium on Diseases in Asian Aquaculture (DAA VI), Aquatic animal health: facing new challenges (25-28 October 2005). Colombo, Sri Lanka. Oral presentation.

3.Leu J.H., Wang H.C., Kou G.H., Lo C.F. “White spot syndrome virus anti-apoptosis protein WSSV449 is a direct caspase inhibitor” in 7th symposium on Diseases in Asian Aquaculture (DAA VII) (22-26 June 2008). Taipei, Taiwan. Poster presentation. 

4.Leu J.H., Kou G.H., Lo C.F. “Expression, purification, and functional analysis of the anti-apoptosis protein WSSV449 from the white spot syndrome virus” in ASIA-PACIFIC AQUACULTURE 2009 (3-6 November 2009). Kuala Lumpur, Malaysia. Oral presentation.

專書：

1.Leu J.H., Tsai J.M., Lo C.F. White spot syndrome virus. Encyclopedia of Virology, third Edition. Elsevier 2008.

2.Leu J.H., Yang F., Zhang X., Xu X., Kou G.H., Lo C.F. Lesser Known Big DNA Viruses: Whispovirus. Current Topics in Microbiology and Immunology 328 (edited by James L. Van Etten) p197-227. Springer-Verlag Berlin Heidelberg 2009.